| Name | IMMUNO 2 - Consequences of Stress Challenges on stress response systems and Immunity in Space: a multidisciplinary approach |
| Operational Nomenclature | IMMUNO 2 |
| URL | https://hreda.esac.esa.int/hreda/#/pages/investigation;investigationAcronym=Immuno2_ISS |
| DOI | https://doi.org/10.57780/esa-gvavrn6 |
| Platform | ISS |
| HRE-E3P Category | Human Research |
| Mission | Inc43, Inc44, Inc45, Inc46, Inc47, Inc48, Inc49, Inc50, Inc51, Inc52, Inc63, Inc64, Inc65, Inc66, Inc67, Inc68, Inc69 |
| Keywords | ESA Human and Robotic Exploration data, HREDA dataset, Human and Robotic Exploration Data Archive, ESA exploration mission data, human spaceflight experiment data, robotic exploration telemetry dataset, International Space Station experiment data, ISS Columbus module data, microgravity research dataset, life sciences space experiment data, space physiology measurements dataset, radiation exposure measurements spaceflight, life support systems performance data, closed-loop environmental control data, ECLSS telemetry dataset, astronaut biomedical monitoring data, space habitat systems engineering data, robotic surface operations dataset, planetary exploration robotics data, lunar exploration technology demonstration data, Mars analog experiment dataset, in-situ resource utilization ISRU experiment data, space systems engineering telemetry, mission operations engineering data, payload performance dataset, calibrated experiment data products, time-series telemetry data, spaceflight sensor measurements, ESA exploration science archive data, long-duration spaceflight research dataset |
| Team Coordinator Name | Alexander Chouker |
| Version | 1.0 |
| Team Members | Immuno2_ISS |
| Publication | RJ Cohrs, Satish K. Mehta, DS Schmid, DH Gilden, Duane L. Pierson, 2008, Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts, Journal of Medical Virology, 80, 6, 1116-1122, DOI: 10.1002/jmv.21173 Dominique J. De Quervain, Benno Roozendaal, JL McGaugh, 1998, Stress and glucocorticoids impair retrieval of long-term spatial memory, Nature, 394, 787-790 Raymond P. Stowe, Clarence F. Sams, Satish Mehta, I Kaur, M Jones, D Feeback, Duane L. Pierson, 1999, Leukocyte subsets and neutrophil function after short-term space flight, Journal of Leukocyte Biology, 65, 179-186 Raymond P. Stowe, DL Yetman, WF Storm, Clarence F. Sams, Duane L. Pierson, 2008, Neuroendocrine and immune responses to 16-day bed rest with realistic launch and landing G profiles, Aviation, Space, and Environmental Medicine, 79, 2, 117-122 BE Crucian, Raymond P. Stowe, Duane L. Pierson, Clarence F. Sams, 2008, Immune system dysregulation following short- vs long-duration spaceflight, Aviation, Space, and Environmental Medicine, 79, 9, 835-843 BE Crucian, ML Cubbage, Clarence F. Sams, 2000, Altered cytokine production by specific human peripheral blood cell subsets immediately following space flight, Journal of Interferon and Cytokine Research, 20, 6, 547-556, PMID: 10888111 M Infanger, C Ulbrich, S Baatout, M Wehland, R Kreutz, J Bauer, S Vadrucci, Augusto Cogoli, H Derradji, M Neefs, S Küsters, M Spain, M Paul, D Grimm, 2007, Transient and long-term effects of modeled microgravity on human endothelial cells, Journal of Cellular Biochemistry, 101, 6, 1439-1455 Brian E. Crucian, Clarence F. Sams, 2009, Immune system dysregulation during spaceflight: clinical risk for exploration-class missions, Journal of Leukocyte Biology, 86, 5, 1017-1018, DOI: 10.1189/jlb.0709500 Winnok De Vos, Birger Dieriks, Kaat van Oostveldt, Geert Meesen, Myriam Ghardi, S Baatout, Patrick van Oostveldt, 2010, A single cell based cytometry approach to evaluate space radiation effects on normal human fibroblasts during the Foton M3 mission, Radiation Research D Grimm, P Wise, Michael Lebert, Peter Richter, S Baatout, 2011, How and why does the proteome respond to microgravity?, Expert Review of Proteomics, 8, 1, 13-27, DOI: 10.1586/epr.10.105 Claudia Strewe, Matthias Feuerecker, Igor Alexandrovich Nichiporuk, Ines Kaufmann, D Hauer, Boris V. Morukov, Gustav Schelling, Alexander Choukèr, 2012, Effects of parabolic flight and spaceflight on the endocannabinoid system in humans, Reviews in the Neurosciences, 23, 5-6, 673-680 A Krumbholz, P Anielski, N Reisch, Gustav Schelling, Detlef Thieme, 2013, Diagnostic Value of Concentration Profiles of Glucocorticosteroids and Endocannabinoids in Hair, Therapeutic Drug Monitoring, 35, 5, 600-607, DOI: 10.1097/FTD.0b013e3182953e43 D Bentz, T Michael, FH Wilhelm, FR Hartmann, S Kunz, IR von Rohr, Dominique J. De Quervain, 2013, Influence of stress on fear memory processes in an aversive differential conditioning paradigm in humans, Psychoneuroendocrinology, 38, 7, 1186-1197 Matthias Feuerecker, Matthias Feuerecker, W Mayer, W Mayer, Ines Kaufmann, Ines Kaufmann, Markus Gruber, Markus Gruber, F Muckenthaler, F Muckenthaler, B Yi, B Yi, Alex Paddy Salam, Alex Paddy Salam, J Briegel, J Briegel, Gustav Schelling, Gustav Schelling, Manfred Thiel, Manfred Thiel, Alexander Choukèr, Alexander Choukèr, 2013, A corticoid-sensitive cytokine release assay for monitoring stress-mediated immune modulation, Clinical & Experimental Immunology, 172, 2, 290-299, DOI: 10.1111/cei.12049 C Rombouts, A Aerts, M Beck, WH De Vos, Patrick van Oostveldt, MA Benotmane, S Baatout, 2013, Differential response to acute low dose radiation in primary and immortalized endothelial cells, International Journal of Radiation Biology, 89, 10, 841-850, DOI: 10.3109/09553002.2013.806831 Brian E. Crucian, Raymond P. Stowe, Satish Mehta, P Uchakin, H Quiriarte, Duane L. Pierson, Clarence F. Sams, 2013, Immune system dysregulation occurs during short duration spaceflight on board the space shuttle, Journal of Clinical Immunology, 33, 2, 456-465 C Benjamin, Raymond P. Stowe, L St. John, Clarence F. Sams, Satish Mehta, Brian E. Crucian, Duane L. Pierson, K Komanduri, 2016, Decreases in thymopoiesis of astronauts returning from space flight, JCI Insight, 1, 2016;1(12):e88787. DOI:10.1172/jci.insight.88787 Judith-Irina Buchheim, S Matzel, Marina Rykova, G Vassilieva, S Ponomarev, Igor Alexandrovich Nichiporuk, M Hörl, D Moser, K Biere, Matthias Feuerecker, Gustav Schelling, Detlef Thieme, Ines Kaufmann, Manfred Thiel, Alexander Choukèr, 2019, Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight, Frontiers in Physiology, 10, 85, DOI: 10.3389/fphys.2019.00085 ISSN=1664-042X |
| Temporal Coverage | 2015-03-12T00:00:00Z/2023-09-20T00:00:00Z |
| Mission Description | The HRE Data Archive (HREDA) collects information and data of investigations funded or co-funded by ESA’s Directorate for Human and Robotic Exploration (HRE) and performed on microgravity and ground-based facilities since 1972. |
| Creator Contact | https://hreda.esac.esa.int/hreda/#/pages/help/contact |
| Date Published | 2025-11-07T17:35:18Z |
| Last Update | 2026-07-09 |
| Publisher And Registrant | European Space Agency |
| Credit Guidelines | European Space Agency, Alexander Chouker, 2025, 'IMMUNO 2', 1.0, European Space Agency, https://doi.org/10.57780/esa-gvavrn6 |
| Rights | Data hosted in the ESA Space Science Archives are distributed under the CC BY-NC 3.0 IGO license. |