| Name | Regulation of Cell Growth and Differentiation by Microgravity: Retinoic Acid-induced Cell Differentiation |
| Operational Nomenclature | Retinoic Acid-induced Cell Differentiation |
| URL | https://hreda.esac.esa.int/hreda/#/pages/investigation;investigationAcronym=RetinoicAcid_induced_CellDifferentiation_SHUT |
| DOI | https://doi.org/10.57780/esa-7bh8olo |
| Platform | Space Shuttle |
| HRE-E3P Category | Biology |
| Mission | STS-65, IML-2 |
| Keywords | ESA Human and Robotic Exploration data, HREDA dataset, Human and Robotic Exploration Data Archive, ESA exploration mission data, human spaceflight experiment data, robotic exploration telemetry dataset, International Space Station experiment data, ISS Columbus module data, microgravity research dataset, life sciences space experiment data, space physiology measurements dataset, radiation exposure measurements spaceflight, life support systems performance data, closed-loop environmental control data, ECLSS telemetry dataset, astronaut biomedical monitoring data, space habitat systems engineering data, robotic surface operations dataset, planetary exploration robotics data, lunar exploration technology demonstration data, Mars analog experiment dataset, in-situ resource utilization ISRU experiment data, space systems engineering telemetry, mission operations engineering data, payload performance dataset, calibrated experiment data products, time-series telemetry data, spaceflight sensor measurements, ESA exploration science archive data, long-duration spaceflight research dataset |
| Team Coordinator Name | SW De Laat |
| Version | 1.0 |
| Publication | PJ Rijken, J Boonstra, AJ Verkleij, SW De Laat, 1994, Effects of gravity on the cellular response to epidermal growth factor, Adv. Space Biol. Med., Vol. 45, 159-188 RP De Groot, PJ Rijken, J den Hertog, J Boonstra, AJ Verkleij, SW De Laat, W Kruijer, 1991, Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes, Experimental Cell Research, 197, 1, 87-90 PJ Rijken, RP De Groot, W Briegleb, W Kruijer, AJ Verkleij, J Boonstra, SW De Laat, 1991, Epidermal growth factor-induced cell rounding is sensitive to simulated gravity, Aviat. Space Env. Med., Vol. 62, 32-36 PJ Rijken, RP De Groot, W Kruijer, SW De Laat, AJ Verkleij, J Boonstra, 1992, Identification of specific gravity sensitive signal transduction pathways in human A431 carcinoma cells, Adv. Space Res., Vol. 12, 145-152 J Boonstra, 1997, Growth factor-induced signal transduction in mammalian cells is sensitive to gravity, Life Sciences Experiments Performed on Sounding Rockets (1985-1994), ESA SP-1206, 53-57, Augusto Cogoli, U Friedrich, D Mesland, René Demets SW De Laat, 1997, Replication of cell growth and differentiation by microgravity: retinoic acid-induced cell differentiation (Mouse), Second International Microgravity Laboratory (IML-2) - Final Report, NASA RP-1405, 130-131, RS Snyder J Boonstra, PJ Rijken, RP De Groot, AJ Verkleij, PT Van der Saag, SW De Laat, 1997, Growth factor-induced signal transduction in mammalian cells is sensitive to gravity, Frontiers of Biological Science in Space, , 2-18, A Sato, Taiyo Printings Sales Co., Ltd., Toky J Boonstra, 1999, Growth factor-induced signal transduction in adherent mammalian cells is sensitive to gravity, FASEB J., Vol. 13, S35-S42 RP De Groot, PJ Rijken, J den Hertog, J Boonstra, AJ Verkleij, SW De Laat, W Kruijer, 1990, Microgravity decreases c-fos induction and serum response element (SRE) activity, J. Cell Science, Vol. 97, 33-38 |
| Temporal Coverage | 1994-07-08T00:00:00Z/1994-07-23T00:00:00Z |
| Mission Description | The HRE Data Archive (HREDA) collects information and data of investigations funded or co-funded by ESA’s Directorate for Human and Robotic Exploration (HRE) and performed on microgravity and ground-based facilities since 1972. |
| Creator Contact | https://hreda.esac.esa.int/hreda/#/pages/help/contact |
| Date Published | 2025-11-08T14:33:31Z |
| Last Update | 2026-03-04 |
| Publisher And Registrant | European Space Agency |
| Credit Guidelines | European Space Agency, Sw De Laat, 2025, 'Retinoic Acid-induced Cell Differentiation', 1.0, European Space Agency, https://doi.org/10.57780/esa-7bh8olo |