| Name | SPHEROIDS - Effects of weightlessness on tube formation, differentiation, and the mechanisms of apoptosis in human endothelial cells |
| Operational Nomenclature | SPHEROIDS |
| URL | https://hreda.esac.esa.int/hreda/#/pages/investigation;investigationAcronym=SPHEROIDS_ISS |
| DOI | https://doi.org/10.57780/esa-l12h1j3 |
| Platform | ISS |
| HRE-E3P Category | Biology |
| Mission | Inc47, Inc48 |
| Team Coordinator Name | Daniela Gabriele Grimm |
| Version | 1.0 |
| Team Members | SPHEROIDS_ISS |
| Publication | J Pietsch, S Gass, S Nebuloni, D Echegoyen, S Riwaldt, C Baake, J Bauer, TJ Corydon, Marcel Egli, M Infanger, D Grimm, 2017, Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission - The SPHEROIDS project, Biomaterials, 124, 126-156, DOI: 10.1016/j.biomaterials.2017.02.005 X Ma, A Sickmann, J Pietsch, R Wildgruber, G Weber, M Infanger, J Bauer, D Grimm, 2014, Proteomic differences between microvascular endothelial cells and the EA.hy926 cell line forming three-dimensional structures, Proteomics, 14, 6, 689-698, DOI: 10.1002/pmic.201300453 X Ma, M Wehland, H Schulz, K Saar, N Hübner, M Infanger, J Bauer, D Grimm, 2013, Genomic approach to identify factors that drive the formation of three-dimensional structures by EA.hy926 endothelial cells, PLoS One, 8, 5, e64402, DOI: 10.1371/journal.pone.0064402 D Grimm, Marcel Egli, M Krüger, S Riwaldt, TJ Corydon, S Kopp, M Wehland, P Wise, M Infanger, V Mann, A Sundaresan, 2018, Tissue Engineering Under Microgravity Conditions-Use of Stem Cells and Specialized Cells, Stem Cells and Development, 27, 12, 787-804, DOI: 10.1089/scd.2017.0242 A Dittrich, D Grimm, J Sahana, J Bauer, M Krüger, M Infanger, NE Magnusson, 2018, Key Proteins Involved in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity, Cellular Physiology and Biochemistry, 45, 2, 429-445, DOI: 10.1159/000486920 M Krüger, S Kopp, M Wehland, J Bauer, S Baatout, M Moreels, Marcel Egli, TJ Corydon, M Infanger, G Grimm, 2019, Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies, Acta Astronautica, 159, 267-272, https://doi.org/10.1016/j.actaastro.2019.03.074 |
| Temporal Coverage | 2016-03-03T00:00:00Z/2016-09-06T00:00:00Z |
| Mission Description | The HRE Data Archive (HREDA) collects information and data of investigations funded or co-funded by ESA’s Directorate for Human and Robotic Exploration (HRE) and performed on microgravity and ground-based facilities since 1972. |
| Creator Contact | https://hreda.esac.esa.int/hreda/#/pages/help/contact |
| Date Published | 2023-06-09T07:44:12Z |
| Last Update | 2024-11-21 |
| Publisher And Registrant | European Space Agency |
| Credit Guidelines | European Space Agency, 2023, 'SPHEROIDS', 1.0, European Space Agency, https://doi.org/10.57780/esa-l12h1j3 |