| Name | SPHEROIDS - Effects of weightlessness on tube formation, differentiation, and the mechanisms of apoptosis in human endothelial cells |
| Operational Nomenclature | SPHEROIDS |
| URL | https://hreda.esac.esa.int/hreda/#/pages/investigation;investigationAcronym=SPHEROIDS_ISS |
| DOI | https://doi.org/10.57780/esa-l12h1j3 |
| Platform | ISS |
| HRE-E3P Category | Biology |
| Mission | Inc47, Inc48 |
| Keywords | ESA Human and Robotic Exploration data, HREDA dataset, Human and Robotic Exploration Data Archive, ESA exploration mission data, human spaceflight experiment data, robotic exploration telemetry dataset, International Space Station experiment data, ISS Columbus module data, microgravity research dataset, life sciences space experiment data, space physiology measurements dataset, radiation exposure measurements spaceflight, life support systems performance data, closed-loop environmental control data, ECLSS telemetry dataset, astronaut biomedical monitoring data, space habitat systems engineering data, robotic surface operations dataset, planetary exploration robotics data, lunar exploration technology demonstration data, Mars analog experiment dataset, in-situ resource utilization ISRU experiment data, space systems engineering telemetry, mission operations engineering data, payload performance dataset, calibrated experiment data products, time-series telemetry data, spaceflight sensor measurements, ESA exploration science archive data, long-duration spaceflight research dataset |
| Team Coordinator Name | Daniela Gabriele Grimm |
| Version | 1.0 |
| Team Members | SPHEROIDS_ISS |
| Publication | X Ma, A Sickmann, J Pietsch, R Wildgruber, G Weber, M Infanger, J Bauer, D Grimm, 2014, Proteomic differences between microvascular endothelial cells and the EA.hy926 cell line forming three-dimensional structures, Proteomics, 14, 6, 689-698, DOI: 10.1002/pmic.201300453 A Dittrich, D Grimm, J Sahana, J Bauer, M Krüger, M Infanger, NE Magnusson, 2018, Key Proteins Involved in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity, Cellular Physiology and Biochemistry, 45, 2, 429-445, DOI: 10.1159/000486920 D Grimm, Marcel Egli, M Krüger, S Riwaldt, TJ Corydon, S Kopp, M Wehland, P Wise, M Infanger, V Mann, A Sundaresan, 2018, Tissue Engineering Under Microgravity Conditions-Use of Stem Cells and Specialized Cells, Stem Cells and Development, 27, 12, 787-804, DOI: 10.1089/scd.2017.0242 J Pietsch, S Gass, S Nebuloni, D Echegoyen, S Riwaldt, C Baake, J Bauer, TJ Corydon, Marcel Egli, M Infanger, D Grimm, 2017, Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission - The SPHEROIDS project, Biomaterials, 124, 126-156, DOI: 10.1016/j.biomaterials.2017.02.005 M Krüger, S Kopp, M Wehland, J Bauer, S Baatout, Marjan Moreels, Marcel Egli, TJ Corydon, M Infanger, G Grimm, 2019, Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies, Acta Astronautica, 159, 267-272, https://doi.org/10.1016/j.actaastro.2019.03.074 X Ma, M Wehland, H Schulz, K Saar, N Hübner, M Infanger, J Bauer, D Grimm, 2013, Genomic approach to identify factors that drive the formation of three-dimensional structures by EA.hy926 endothelial cells, PLoS One, 8, 5, e64402, DOI: 10.1371/journal.pone.0064402 |
| Temporal Coverage | 2016-03-03T00:00:00Z/2016-09-06T00:00:00Z |
| Mission Description | The HRE Data Archive (HREDA) collects information and data of investigations funded or co-funded by ESA’s Directorate for Human and Robotic Exploration (HRE) and performed on microgravity and ground-based facilities since 1972. |
| Creator Contact | https://hreda.esac.esa.int/hreda/#/pages/help/contact |
| Date Published | 2025-11-09T11:33:04Z |
| Last Update | 2026-07-09 |
| Publisher And Registrant | European Space Agency |
| Credit Guidelines | European Space Agency, Daniela Gabriele Grimm, 2025, 'SPHEROIDS', 1.0, European Space Agency, https://doi.org/10.57780/esa-l12h1j3 |
| Rights | Data hosted in the ESA Space Science Archives are distributed under the CC BY-NC 3.0 IGO license. |